{"id":2253,"date":"2017-09-28T10:30:19","date_gmt":"2017-09-28T09:30:19","guid":{"rendered":"http:\/\/www.soshepatites.org\/plateforme\/?page_id=2253"},"modified":"2019-02-28T15:46:21","modified_gmt":"2019-02-28T14:46:21","slug":"la-recherche","status":"publish","type":"page","link":"https:\/\/soshepatites.org\/plateforme\/nash\/la-recherche\/","title":{"rendered":"La recherche"},"content":{"rendered":"<p style=\"text-align: justify;\">La\u00a0NASH est une catastrophe sanitaire annonc\u00e9e, et un fardeau pr\u00e9visible pour les r\u00e9gimes d\u2019assurance maladie. Mais elle repr\u00e9sente aussi un eldorado pour les laboratoires pharmaceutiques,\u00a0 avec un march\u00e9 potentiel \u00e9valu\u00e9 entre 20 et 35 milliards de dollars dans les ann\u00e9es \u00e0 venir.<\/p>\n<p style=\"text-align: justify;\">Les mol\u00e9cules \u00e0 l\u2019\u00e9tude visent plusieurs objectifs\u00a0:<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">&#8211; Les mol\u00e9cules contre l\u2019insulinor\u00e9sistance (metformine, glitazones), dites \u201cinsulinosensibilisantes\u201d, pourraient avoir un r\u00f4le important, en plus du traitement d&rsquo;un \u00e9ventuel diab\u00e8te, \u00e9tant donn\u00e9 le r\u00f4le central de l&rsquo;insulinor\u00e9sistance dans la nash.<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">&#8211; Les inhibiteurs des r\u00e9cepteurs cannabino\u00efdes pourraient avoir un r\u00f4le dans le traitement de l&rsquo;ob\u00e9sit\u00e9, mais certains ont d\u00fb \u00eatre retir\u00e9s pr\u00e9cocement du march\u00e9 en raison d\u2019effets secondaires importants.<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">&#8211; Les m\u00e9dicaments h\u00e9patoprotecteurs comme l&rsquo;acide ursod\u00e9soxycholique \u00e0 forte dose ou la phosphatidylcholine font \u00e9galement l&rsquo;objet d&rsquo;essais th\u00e9rapeutiques.<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">&#8211; Les antioxydants, \u00a0de type vitamine E, n&rsquo;ont pas encore fait pour l&rsquo;instant la preuve de leur efficacit\u00e9, mais restent une piste \u00e9tudi\u00e9s.<\/p>\n<p style=\"text-align: justify; padding-left: 30px;\">&#8211; D&rsquo;autres mol\u00e9cules pourraient \u00e9galement avoir un int\u00e9r\u00eat, comme certains hypolipemiants (fibrates, statines, gemfibrozil) ou la pentoxyphilline.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-2509\" src=\"http:\/\/www.soshepatites.org\/plateforme\/wp-content\/uploads\/2017\/09\/NASH-MOLECULES-2.jpg\" alt=\"\" width=\"696\" height=\"967\" srcset=\"https:\/\/soshepatites.org\/plateforme\/wp-content\/uploads\/2017\/09\/NASH-MOLECULES-2.jpg 696w, https:\/\/soshepatites.org\/plateforme\/wp-content\/uploads\/2017\/09\/NASH-MOLECULES-2-216x300.jpg 216w, https:\/\/soshepatites.org\/plateforme\/wp-content\/uploads\/2017\/09\/NASH-MOLECULES-2-65x90.jpg 65w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><\/p>\n<p>(Source\u00a0: L. Serfaty, Forum SOS H\u00e9patites 2016.)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La\u00a0NASH est une catastrophe sanitaire annonc\u00e9e, et un fardeau pr\u00e9visible pour les r\u00e9gimes d\u2019assurance maladie. Mais elle repr\u00e9sente aussi un eldorado pour les laboratoires pharmaceutiques,\u00a0 avec un march\u00e9 potentiel \u00e9valu\u00e9 entre 20 et 35 milliards de dollars dans les ann\u00e9es \u00e0 venir. Les mol\u00e9cules \u00e0 l\u2019\u00e9tude visent plusieurs objectifs\u00a0: &#8211; Les mol\u00e9cules contre l\u2019insulinor\u00e9sistance (metformine, &hellip; <a href=\"https:\/\/soshepatites.org\/plateforme\/nash\/la-recherche\/\" class=\"more-link\">Continuer la lecture de <span class=\"screen-reader-text\">La recherche<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2248,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"page-templates\/pf2-na-page-sans-article.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2253","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La recherche - nous sommes H\u00c9PATANTS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/soshepatites.org\/plateforme\/nash\/la-recherche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La recherche - nous sommes H\u00c9PATANTS\" \/>\n<meta property=\"og:description\" content=\"La\u00a0NASH est une catastrophe sanitaire annonc\u00e9e, et un fardeau pr\u00e9visible pour les r\u00e9gimes d\u2019assurance maladie. 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